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本文报道接种SRS肿瘤后,带瘤小鼠的脾脏细胞具有非特异性抑制体外同种异型细胞(MLR)和淋巴细胞对致分裂原刺激的增生反应。这种抑制效应在肿瘤接种后3天即可观察到,其中以粘附细胞的抑制作用为明显,从带瘤10天、20天、33天小鼠脾脏组分出来的粘附细胞,对刀豆素A(ConA),大肠杆菌脂多糖(LPS)诱发淋巴细胞增生反应的抑制率均可达90％以上。用~(60)钴2500rad照射或用抗Thy-1血清和补体处理这种脾脏粘附细胞,只能部分地消除它的抑制作用,提示很可能是通过粘附细胞中的巨噬细胞发挥作用,但也不能排除T细胞在其中也起一定的作用。
In this report, it is reported that spleen cells of tumor-bearing mice have non-specific inhibition of proliferation responses to mitogenic stimulation of allogenic allogeneic cells (MLRs) and lymphocytes after inoculation with SRS tumors. This inhibitory effect was observed 3 days after tumor inoculation, in which the inhibitory effect of adherent cells was obvious, and adherent cells from the spleen components of the mice with tumors of 10 days, 20 days, and 33 days were observed. The inhibitory rate of lymphocyte proliferation induced by ConA and E. coli lipopolysaccharide (LPS) can reach more than 90%. Treatment with ~(60) Cobalt 2500rad or treatment of this spleen-adherent cell with anti-Thy-1 serum and complement can only partially eliminate its inhibitory effect, suggesting that it is likely to act through macrophages in adherent cells. However, it cannot be ruled out that T cells also play a role in it.