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Picton和Chisholm描述了1例与大剂量静注丙球相关的无菌脑膜炎病例,他们是根据脑脊髓液中的嗜酸性细胞而诊断的。这种副作用表现各异,从注射后短暂头痛到呕吐、畏光、脖子僵硬和严重头痛。虽然大部分发生在治疗后的48小时内,这些症状的时限可能延续至7天,这些症状不常复现,特别是比较轻微时,其机理不明,任何治疗都是凭经验的。 一些方法有助于那些需要进行大剂量静注丙球的病人。开始治疗时使用低流速和丙球稀溶液。首次剂量(总量为2g/kg)以3％溶液在大于5天的时
Picton and Chisholm describe a case of aseptic meningitis associated with high-dose IV cues diagnosed based on eosinophils in cerebrospinal fluid. This side effect varies from brief headache after injection to vomiting, photophobia, stiff neck, and severe headaches. Although most occur within 48 hours of treatment, the duration of these symptoms can last up to 7 days and these symptoms are infrequent recurrences, especially at milder times, where the mechanism is unknown and any treatment is experienced. Some methods are helpful for those patients who need high-dose intravenous corticosteroids. Use low flow and dilute solutions when starting treatment. The first dose (2g / kg total) is in 3% solution for more than 5 days