论文部分内容阅读
目的通过探讨正常早孕妇女和有复发性流产史的早孕妇女之间绒毛及蜕膜组织中趋化因子12(CXCL12)的表达,了解CXCL12在妊娠中的作用。方法通过免疫组织化学分别检测30例正常早孕妇女和有复发性流产史的早孕妇女绒毛及蜕膜组织中CXCL12的表达情况。结果正常早孕妇女与有复发性流产史的早孕妇女绒毛组织和蜕膜组织中CXCL12的表达比较,差异均有统计学意义(P均<0.05)。结论在妊娠早期绒毛及蜕膜组织中CXCL12的表达下降,可能在不明原因复发性流产的发生中起着重要作用。
Objective To investigate the role of CXCL12 in pregnancy by exploring the expression of chemokine 12 (CXCL12) in the chorion and decidua between normal pregnant women and early pregnant women with recurrent spontaneous abortion. Methods The expression of CXCL12 in villi and decidua of 30 normal pregnant women and the pregnant women with recurrent spontaneous abortion were detected by immunohistochemistry respectively. Results The expression of CXCL12 in normal early pregnancy women and early pregnancy women with recurrent spontaneous abortion had significant difference (all P <0.05). Conclusion The decreased expression of CXCL12 in early pregnancy may play an important role in the occurrence of unexplained recurrent spontaneous abortion.