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为观察泰诺龙对泌尿上皮的副作用，将实验大鼠分为两组：①用药组３５只，分别用泰诺龙处理２、４、６、９、１２、１４、１６、１８、２０、２４、３０周，各时间段动物数２～４只，剂量为６０～８０ｍｇ／ｋｇ体重；②对照组２２只，各时间段动物数２只。光镜观察，用药６周以上的大鼠泌尿道上皮细胞和上皮下成纤维细胞以及巨噬细胞胞浆内出现许多颗粒和空泡。电镜结合组化染色显示，后者为次级溶酶体，含多量髓样结构或层状体，或有硫酸氨基多糖贮积。实验结果说明该药的副作用累及泌尿道粘膜。泌尿上皮主要表现为脂类沉积；上皮下成纤维细胞和巨噬细胞则主要出现粘多糖沉积症样改变。
In order to observe the side effects of Tylenolon on urothelial cells, the experimental rats were divided into two groups: (1) 35 drug-treated rats were treated with tenonon for 2,4,6,9,12,14,16,18,20, 24 and 30 weeks, each time period, the number of animals 2 to 4, the dose of 60 ~ 80mg / kg body weight; ② control group of 22, the number of animals in each time period 2. Light microscopy showed that there were many granules and vacuoles in the rat urothelial cells and sub-epithelial fibroblasts and macrophage cytoplasm over 6 weeks. Electron microscopy combined with histochemical staining showed that the latter is a secondary lysosome containing a large amount of myeloid structure or lamellar body or having sulfated polysaccharides. The experimental results show that side effects of the drug involving the urinary tract mucosa. Urinary epithelium is mainly manifested as lipid deposition; subepithelial fibroblasts and macrophages are mainly mucopolysaccharidosis-like changes.