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穿心莲,学名Andrographis paniculata Ness.为爵床科(Acanthaceae)穿心莲属一年生草本植物,又名一见喜,榄核莲,印度草,苦胆草。原产热带、亚热带地区,喜温暖、向阳和湿润环境,我国南方各省都可栽培。有清热、解毒,消炎等功用。所含几种主要成分均属内酯类。 广东省梅县地区人民医院用穿心莲提取物治疗恶性滋养叶肿瘤有效。但抗瘤有效成分未明,所用的氯仿提取物难溶于水,妨碍配成含量恒定的注射制剂,影响疗效的稳定性。因此必须分离和确定穿心莲抗恶性滋养叶肿瘤细胞的有效成分,通过实验研究,找出抗滋养叶细胞作用的根据。尤其希望制取有效成分的水溶性制剂,方便应用,并保证制剂的含量。抗滋养叶细胞的成分除可用于抗绒癌外,亦可能用于终止早,中期妊娠。
Andrographis paniculata Ness is the annual herb of the family Acanthaceae (Annanthus), also known as the lovage, the lavender, the Indian grass, and the bitter bile grass. Native to tropical and subtropical regions, hi, warm, sunny, and humid environments can be cultivated in the southern provinces of China. There are heat, detoxification, anti-inflammatory and other functions. The main components contained are lactones. The use of extract of Andrographis paniculata in Meixian District People’s Hospital of Guangdong Province is effective for the treatment of malignant neoplasm tumors. However, the effective antitumor component is not known, and the chloroform extract used is hardly soluble in water, which prevents the formulation of a constant amount of the injection preparation and affects the stability of the therapeutic effect. Therefore, it is necessary to isolate and determine the effective components of the anti-gonadotrophoblast tumor cells in andrographis paniculata, and to find the basis for the effect of anti-trophoblastic cells through experimental studies. In particular, it is desirable to prepare a water-soluble formulation of the active ingredient for convenient application and to ensure the content of the formulation. In addition to being used against choriocarcinoma, it may also be used to terminate early and mid-term pregnancies.