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作者从1987年开始通过内镜对幽门螺杆菌(Helicobacter pylori简称HP)感染密度与消化性溃疡的关系进行了研究。内镜确诊的消化性溃疡(peptic ulcer,简称pu)766例中,有24.8％的患者胃窦粘膜检出了不同密度的Hp感染,从而支持该菌是消化性溃疡病原的学说。胃窦Hp感染的密度分布,O级25.20％(193/766),Ⅰ级为45.95％(352/766),2级为15.27％(117/766),3级为13.58％(104/766)。作者采用治疗Pu及清除Hp相结合,局部治疗与系统治疗相结合的综合治疗。结果PU治愈率100％,其中Pu治愈伴细菌清除者为88.88％,其中11.12％Pu治愈而Hp仍存在,其Hp感染密度皆为3级。而HP继续存在的病例,PU累积一年复发率为5.74％,在193例无Hp感染的Pu患者中,有5例复发,复发率为2.59％(5/193累积1年复发率)。Hp感染密度分析表明:Hp感染可能是Pu的病原,治Pu与Hp结合,局部治疗与系统疗法相结合,是短程高效及低复发率的根本。
The authors studied the relationship between Helicobacter pylori (HP) infection density and peptic ulcer disease by endoscopy through endoscopy in 1987. Endoscopic confirmed peptic ulcer (peptic ulcer, referred to as pu) 766 cases, 24.8% of patients with gastric antral mucosa detected different density of Hp infection, thus supporting the bacteria is the theory of peptic ulcer pathogens. The density distribution of gastric antrum Hp infection was 25.20% (193/766) in O class, 45.95% (352/766) in grade I, 15.27% (117/766) in grade 2 and 13.58% (104/766) in grade 3, . The authors used the treatment of Pu and clear Hp combination of local treatment and systemic treatment combined with comprehensive treatment. Results The cure rate of PU was 100%, among which 88.88% was cured by Pu accompanied by bacterial clearance, and 11.12% Pu was cured while Hp was still present. The density of Hp infection was all grade 3. In HP cases, the one-year recurrence rate of PU was 5.74%. Among 193 cases of Pu without Hp infection, 5 cases relapsed and the recurrence rate was 2.59% (5/193 cumulative one-year recurrence rate). Hp infection density analysis showed that: Hp infection may be the pathogen of Pu, treatment of Pu and Hp, local treatment combined with systemic therapy is the basis of short-term high efficiency and low recurrence rate.