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目的:探讨原发性肝细胞癌(HCC)Sonic hedgehog信号通路信号肽Shh、膜受体Ptch-1和核转录因子Gli-2的表达及其生物学意义。方法:将44例HCC组织及其相应的癌旁肝组织制成含88个微组织的组织芯片,采用免疫组织化学方法分别检测了Shh、Ptch-1和Gli-2在两种组织中的表达情况。结果:在HCC组织中,Shh与Ptch-1阳性率(63.6%和45.5%)均显著高于癌旁肝组织(36.4%和25.0%),P均<0.05。Gli-2在HCC中表达阳性率(68.2%)显著高于癌旁肝组织(38.6%),P<0.01;且与HCC的组织学分级以及侵袭性相关,P均<0.05;与肿瘤大小和HBV感染无关。结论:增强的Gli-2活性导致细胞异常增殖,其所引起的Shh信号通路的过度激活可能促进HCC的发生和发展。
Objective: To investigate the expression of Sile hedgehog signaling pathway signal peptide Shh, membrane receptor Ptch-1 and nuclear transcription factor Gli-2 in primary hepatocellular carcinoma (HCC) and its biological significance. Methods: Forty-eight HCC tissues and corresponding adjacent liver tissues were made into tissue microarrays containing 88 microstructures. Immunohistochemistry was used to detect the expression of Shh, Ptch-1 and Gli-2 in the two tissues Happening. Results: The positive rates of Shh and Ptch-1 (63.6% and 45.5%) in HCC tissues were significantly higher than those in para-cancerous liver tissues (36.4% and 25.0%, P <0.05 respectively). The positive rate of Gli-2 expression in HCC (68.2%) was significantly higher than that in adjacent non-cancerous liver tissue (38.6%, P <0.01), and correlated with histological grade and invasiveness of HCC (P <0.05) HBV infection has nothing to do. CONCLUSION: The enhanced Gli-2 activity leads to abnormal cell proliferation. The over-activation of Shh signaling pathway may promote the occurrence and development of HCC.