【摘 要】
:
磷脂酶参与细胞跨膜信息传递,磷脂酶A2还是机体炎症、过敏介质产生的关键酶。因此,磷脂酶抑制剂的合成研究对研究细胞表达某种功能的信息传递机制及与磷脂酶A2激活相关的疾病治疗机
【机 构】
:
辽宁师范大学化学系,大连医科大学生化教研室
论文部分内容阅读
磷脂酶参与细胞跨膜信息传递,磷脂酶A2还是机体炎症、过敏介质产生的关键酶。因此,磷脂酶抑制剂的合成研究对研究细胞表达某种功能的信息传递机制及与磷脂酶A2激活相关的疾病治疗机制和药物研究具有重要意义。本文主要综述了近期有关磷脂酶A2抑制剂的合成、结构、抑效性能、构效关系及应用前景等,对磷脂酶C和磷脂酶D的抑制剂作了简要介绍。
Phospholipase involved in cell transmembrane information transmission, phospholipase A2 or the body inflammation, allergic media generated by the key enzyme. Therefore, the synthesis of phospholipase inhibitors is of great importance to study the mechanism of information transmission of cells to express certain functions and to the treatment mechanism of diseases associated with phospholipase A2 activation and to drug research. This review summarizes the recent studies on the synthesis, structure, inhibitory potency, structure-activity relationship and application prospect of phospholipase A2 inhibitors, and briefly introduces the inhibitors of phospholipase C and phospholipase D.
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