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目的 研究放线菌属产生的阿凡曼菌素 Ｂ１ 的衍生物伊维菌素（ Ｉｖｅｒｍ ｅｃｔｉｎ） 搽剂皮肤用药的急性和长期毒性作用。方法 观察给予正常皮肤和破损皮肤动物一次性或长期经皮给药产生的毒性反应。结果 以２６７ｍ ｇ／ｋｇ 大剂量的伊维菌素经皮给药 ２４ｈ 后出现震颤、运动失调等中毒症状， ７２ｈ 后症状消失； 以１００ｍ ｇ／ｋｇ 经皮给药 ４５ 天后无明显的毒性。结论 大剂量 （２６７ ｍ ｇ／ｋｇ） 的伊维菌素经破损皮肤给药可致动物急性中毒， 较大剂量 （１００ ｍ ｇ／ｋｇ） 长期皮肤用药无明显的毒性作用。
Aim To study the acute and long-term toxic effects of Ivermectin liniment dermal drug, a derivative of avermectin B1 produced by actinomycetes. Methods Toxicities of single or long-term transdermal administration to normal and damaged skin animals were observed. Results After 24 h transdermal administration of ivermectin at a dose of 267 m g / kg, symptoms such as tremor and ataxia were observed. After 72 h, the symptoms disappeared. After transdermal administration at 100 m g / kg for 45 days, no obvious toxicity was observed. Conclusion High dose (267 m g / kg) of ivermectin can cause acute poisoning in the skin of severely damaged animals. Long-term high dose (100 m g / kg) of skin care has no obvious toxicity.