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目的:探讨老年2型糖尿病(T2DM)应用甘精胰岛素(Gla)联合阿卡波糖(Aca)治疗的有效性与安全性。方法:选取我院2015年1月~2016年5月收治的126例老年T2DM患者,按照随机数字表法均分为两组。对照组:采取预混胰岛素30R(预混30R)+Aca治疗;观察组:应用Gla+Aca治疗。记录比较两组治疗前后胰岛素抵抗指数(HOMA-IR)、餐后2h血糖(2hPG)及空腹血糖(FBG)水平,治疗期间不良反应。结果:与治疗前比较,两组治疗后HOMA-IR、2hPG及FBG水平均显著降低(P<0.01),且观察组改善程度较对照组相比,更为显著(P<0.01);两组不良反应比较,差异无统计学意义(P>0.05)。结论:老年T2DM应用Gla联合Aca治疗效果切实,具有较高临床推广价值。
Objective: To investigate the efficacy and safety of the combination of Gla and Aca in senile type 2 diabetes mellitus (T2DM). Methods: A total of 126 elderly patients with T2DM admitted to our hospital from January 2015 to May 2016 were randomly divided into two groups according to random number table. Control group: Take premixed insulin 30R (premixed 30R) + Aca treatment; observation group: Gla + Aca treatment. The HOMA-IR, 2hPG and FBG levels were recorded and compared before and after treatment. Adverse reactions were observed during the treatment. Results: The levels of HOMA-IR, 2hPG and FBG in the two groups were significantly decreased (P <0.01), and the improvement in the observation group was more significant than that in the control group (P <0.01) Adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion: Glaucoma combined with Aca in elderly T2DM is effective and has high clinical value.