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青霉素和氨基糖甙类药物联合应用是治疗胆道感染的首选方法,但是对年迈、脓毒性和黄疸病人常常伴有肾功能低下者,应选用对肾脏毒性较低的新型抗生素以取代氨基糖甙类药物。作者在20个月期间对106例胆感染病人(急性胆囊炎、急性胆管炎各53例)进行前瞻性随机观察氨苄青霉素加妥布霉素,头孢呱酮和哔呱青霉素的效果. 孕妇对、该类药物过敏抑或已知耐药者,已用其它有效抗生素治疗以及预计在48小时内死亡者均不为研究对象。用药方法及剂量:所用抗生素均以静脉滴注,至少使用5天。氨苄青霉素2克,每6小时一次;妥布
Penicillin and aminoglycosides combined treatment is the preferred method of treatment of biliary tract infections, but elderly, septic and jaundice patients are often associated with renal dysfunction, should use a lower toxicity of the new kidney antibiotics to replace aminoglycosides drug. In a 20-month period, the authors performed a prospective randomized prospective randomized study of ampicillin plus cebecornin, cefotaxime and beripacillin in 106 patients with gall bladder disease (acute cholecystitis, acute cholangitis, 53 cases) None of the subjects who were allergic or known to be resistant to these drugs, who had been treated with other effective antibiotics and who were expected to die within 48 hours. Medication methods and dosage: antibiotics are used intravenously, at least for 5 days. Ampicillin 2 grams, once every 6 hours;