论文部分内容阅读
目的探讨短期胰岛素强化治疗对新诊断2型糖尿病患者血尿酸水平的影响。方法 48例新诊断2型糖尿病患者应用基础-餐时胰岛素强化治疗方案治疗2周,测定治疗前后血尿酸(UA)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS),计算胰岛素抵抗指数(HOMA-IR)和胰岛素敏感指数(ISI)。结果治疗后患者UA、FPG、2hPG、HbA1c、HOMAIR均较治疗前明显下降(P<0.05),ISI明显升高(P<0.05),而FINS治疗前后差异无统计学意义(P>0.05)。结论短期胰岛素强化治疗可有效改善2型糖尿病患者的胰岛素抵抗,降低血尿酸水平。
Objective To investigate the effect of short-term intensive insulin therapy on serum uric acid level in newly diagnosed type 2 diabetic patients. Methods Forty-eight patients with newly diagnosed type 2 diabetes mellitus (T2DM) were enrolled in this study. They were treated with intensive insulin therapy for two weeks. The levels of serum UA, FPG, 2hPG, HbA1c ), Fasting insulin (FINS), calculated insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI). Results After treatment, the levels of UA, FPG, 2hPG, HbA1c and HOMAIR were significantly decreased (P <0.05) and ISI was significantly higher (P <0.05), but no significant difference was found between before and after treatment (P> 0.05). Conclusion Short-term intensive insulin therapy can effectively improve insulin resistance in type 2 diabetic patients and lower serum uric acid levels.