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目的:观察促红细胞生成素(EPO)对早产儿贫血及早期神经行为发育的影响。方法:将61例早产儿随机分为两组,治疗组31例,对照组30例。两组基础治疗相同,包括常规补充维生素E、叶酸和铁剂,治疗组在此基础上给予EPO治疗。观察两组患儿的血红蛋白、红细胞压积、网织红细胞计数,并于纠正胎龄满40周时进行新生儿行为神经测定(NBNA)检查。结果:随着年龄的增大,两组早产儿血红蛋白和红细胞压积均逐渐下降,观察组下降幅度较对照组下降的幅度小(P<0.01);观察组于治疗后网织红细胞明显上升,与对照组比较差异有统计学意义(P<0.01);早产儿在纠正胎龄满40周时的NBNA评分治疗组(37.9±0.71)分高于对照组(35.9±1.51)分(P<0.01)。结论:系统应用外源性的EPO能提高早产儿的血红蛋白、红细胞压积、网织红细胞数,防治早产儿贫血,同时能促进早产儿神经系统的发育。
Objective: To observe the effect of erythropoietin (EPO) on anemia and early neurobehavioral development in preterm infants. Methods: 61 preterm infants were randomly divided into two groups: 31 cases in the treatment group and 30 cases in the control group. The two groups of basic treatment the same, including conventional vitamin E, folic acid and iron, the treatment group on the basis of EPO treatment. The hemoglobin, hematocrit and reticulocyte count of the two groups were observed. Neonatal behavioral nerve assay (NBNA) was performed at 40 weeks after correction of gestational age. Results: The hemoglobin and hematocrit of preterm infants in both groups decreased gradually with the increase of age, and the decreasing rate in observation group was smaller than that in control group (P <0.01). The reticulocyte in observation group increased obviously after treatment, (P <0.01). Compared with the control group (35.9 ± 1.51), the NBNA score of the preterm infants at the age of 40 weeks corrected was higher than that of the control group (P <0.01) ). Conclusion: Exogenous EPO can increase the hemoglobin, hematocrit and reticulocyte in preterm infants and prevent anemia in premature infants, and promote the development of nervous system in premature infants.