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目的探讨无创双水平气道正压(BiPAP)通气联合纳洛酮在Ⅱ型呼吸衰竭合并肺性脑病患者中的应用。方法 72例Ⅱ型呼吸衰竭合并肺性脑病患者分为2组,对照组进行常规综合治疗,治疗组在其基础上使用纳洛酮首次0.8mg静脉注射,随后予3μg/(kg·h)微量泵持续静脉泵入,持续使用无创呼吸机双水平正压通气,观察两组疗效。结果治疗组和对照组治疗的成功率分别为68.57%,43.24%;气管插管率分别为17.14%、37.84%;死亡率分别为11.43%,32.43%,差异均有统计意义(P<0.05)。结论 BiPAP通气联用纳洛酮治疗Ⅱ型呼吸衰竭合并肺性脑病临床疗效确切。
Objective To investigate the application of noninvasive bi-level positive airway pressure (BiPAP) ventilation combined with naloxone in type Ⅱ respiratory failure patients with pulmonary encephalopathy. Methods 72 cases of type Ⅱ respiratory failure with pulmonary encephalopathy were divided into two groups. The control group was treated with conventional combination therapy. The treatment group received intravenous injection of naloxone 0.8 mg for the first time, followed by intravenous injection of 3 μg / (kg · h) Pump continuous intravenous pump, continuous use of non-invasive ventilator bi-level positive pressure ventilation, observed two groups of curative effect. Results The success rates of treatment and control were 68.57% and 43.24% respectively. The rates of tracheal intubation were 17.14% and 37.84%, respectively. The mortality rates were 11.43% and 32.43% respectively, with significant difference (P <0.05) . Conclusion BiPAP ventilation combined with naloxone in the treatment of respiratory failure combined with pulmonary encephalopathy clinical curative effect.