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为探讨急性心肌梗塞溶栓治疗梗塞相关冠状动脉再通对长期预后的影响。自１９９１年７月至１９９５年１月按本课题研究方案对急性心肌梗塞溶栓治疗急性期生存出院的患者作为研究对象。血管再通按临床再通标准判定。本课题组３６所医院共随诊了１２６７例，其中再通组８４３例，平均随诊１６．０≤±１０．４个月，未通组４２４例，平均随诊１９．２±１２．２个月。以死亡作为终点或随诊截止于１９９５年３月底。血管再通组与未通组相比：（１）心脏原因死亡分别为２．８５％与４．７２％（时序检验Ｐ＞０．１）；（２）Ｋａｐｌａｎ－Ｍｅｉｅｒ曲线３年生存率分别为９１．６％和７３．９％（时序检验Ｐ＜０．００１）；（３）再梗塞发生率分别为５．６９％和５．９０％，两者相近；（４）１２６７例Ｃｏｘ回归模式对随访生存分析结果，血管再通是独立因素，较未通者生存机会增加３３．５％，复发再梗塞１次减少生存机会３６．５％。年龄和梗塞部位也是独立因素。
To investigate the impact of thrombolytic therapy of acute myocardial infarction on the long-term prognosis of infarct-related coronary recanalization. From July 1991 to January 1995 according to the research project of acute myocardial infarction in patients with thrombolytic therapy of acute exacerbation of patients discharged as the research object. Vascular recanalization by clinical recanalization standards. The group of 36 hospitals followed up a total of 1267 cases, of which 843 cases recanalization group, the average follow-up of 16.0 ≤ ± 10.4 months, 424 cases of failing group, the average follow-up of 19.2 ± 12.2 Months. End of death or follow-up ends in March 1995. The revascularization group compared with the non-through group: (1) Cardiac cause death was 2.85% and 4.72% respectively (sequence test P> 0.1); (2) The 3-year Kaplan-Meier survival rates were (P <0.001); (3) the incidence of reinfarction was 5.69% and 5.90% respectively, which were similar to each other; (4) 1267 Cox regression Mode of follow-up survival analysis results, vascular recanalization is an independent factor, compared with 33.5% chance of survival of non-through, recurrent and recurrent 1 times reduce the chance of survival 36.5%. Age and infarct sites are also independent factors.