静脉血栓栓塞的治疗方法是先使用普通肝素或低分子量肝素,然后使用维生素K拮抗剂。Buller等研究了活化凝血因子Ⅹ的长效抑制剂idraparinux替代常规疗法的可能性。进行了两项随机的、标签公开的非劣效性试验(noninferiority trials),包括2904名深部静脉血栓形成患者和2215位肺动 Venous thromboembolism is treated by unfractionated heparin or low molecular weight heparin followed by vitamin K antagonists. Buller et al. Studied the possibility that idraparinux, a long-acting inhibitor of activated clotting factor X, would replace conventional therapies. Two randomized, tagged noninferiority trials were conducted, including 2904 patients with deep venous thrombosis and 2215 patients with pulmonary