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Objective:The aim of this study was to discuss HIF-1αexpression and vasculogenic mimicry (VM) in hepatocel-lular carcinoma (HCC) and their relationship with the clinical pathological features and clinical significance. Methods:Two hundred and seven specimens from patients in The Af iliated Hospital of North Sichuan Medical Col ege who received hepatic cellcarcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-1α, VM, and analysed the relationship between clinical pathology. Results:The HIF-1αpositive rate was 71.01%and its expression was associated with liver cirrhosis, tumor size and TNM stage (P