本文报告87例绝经后晚期乳腺癌患者应用己烯雌酚、环磷酰胺和5-氟脲嘧啶(DES+CTX+FU)联合治疗的效果,并与单用DES 或仅用CTX+FU 治疗的疗效进行对比。还分析经用DES 后疗效较高的患者再加用OTX+FU 能否提高疗效,并对联合用药(DES+CTX+FU)与序贯用药(DES→CTX+Fu)孰优孰劣进行了探讨。患者按雌激素受体(ER)情况分为高含量组(ER This article reports the efficacy of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES+CTX+FU) in 87 postmenopausal patients with advanced breast cancer, and compares it with the efficacy of DES alone or CTX+FU alone. . We also analyzed whether adding OTX+FU to patients with higher curative effect after DES can improve the curative effect, and performed a combination of DES+CTX+FU and sequential use of DES→CTX+Fu. Explore. Patients were divided into high-level groups according to estrogen receptor (ER) status (ER