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目的探讨血清心肌酶活性在判断新生儿窒息是否有缺氧缺血性脑病（ＨＩＥ）及其它并发症的参考价值。方法设对照组（２４例）和新生儿窒息组（３１例），并在新生儿窒息组中分设ＨＩＥ组、无合并症组、合并症组，分别测定血清中ＬＤＨ、α－ＨＢＤＨ、ＣＰＫ、ＣＫ－ＭＢ的活性，并作对比分析。结果对照组和新生儿窒息组的两组心肌酶活性比较中ＣＫ－ＭＢ差异显著（Ｐ＜００１），ＨＩＥ组和窒息合并症组与窒息无合并症组的心肌酶活性比较有明显升高（Ｐ＜００５）。结论血清中ＣＫ－ＭＢ作为新生儿窒息心肌损害的生化指标特异性强。血清中ＣＫ－ＭＢ等心肌酶活性升高程度对判断新生儿窒息是否有ＨＩＥ及其它并发症的存在有一定的参考价值。
Objective To investigate the value of serum myocardial enzyme activity in determining neonatal asphyxia with hypoxic-ischemic encephalopathy (HIE) and other complications. Methods The control group (24 cases) and neonatal asphyxia group (31 cases) were divided into two groups: HIE group, non-complication group and comorbidity group. Serum LDH, α-HBDH, CPK, CK-MB activity, and for comparative analysis. Results There were significant differences in CK-MB between the two groups in the control group and the neonatal asphyxia group (P <001). The myocardial enzymes in the HIE group, the asphyxia group and the asphyxia group were significantly increased High (P <005). Conclusions Serum CK-MB is a biochemical indicator of neonatal asphyxia myocardial damage. Serum CK-MB and other myocardial enzyme activity increased to determine the extent of neonatal asphyxia HIE and other complications there is a certain reference value.