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绪言一,般治疗概念,例多肽(和某些药物),无法给病人口服治疗,因为消化液所破坏。胰岛素唯一给药途径,以注射方式,如果口服,则必然为胃肠辺解朊酶所降解失效。如果糖尿病人无法接受胰岛素治疗,那么是个大问题了,因此想法设计胰岛素按口服方式给药,又不损害药物的生物活性。曾设计胰岛素盐酸盐与血管扩张药混合压片,作成舌下给药方式,已获成功,然而长期大剂量给药,非生理需要血管缓张剂,仍然是个问题。
Introduction First, the concept of general treatment, such as peptides (and some drugs), can not be given orally to patients because digestive juice is destroyed. The only route of administration of insulin, injection, if oral, it is inevitable for the degradation of gastrointestinal Xuan prioninase failure. If people with diabetes can not accept insulin treatment, then it is a big problem, so the idea of designing insulin administered orally without compromising the biological activity of the drug. The combination of insulin hydrochloride and a vasodilator has been designed to be sublingual and has been successful, however, long-term high-dose administration of non-physiologic vascular relaxants remains a problem.