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作者们通过家兔实验研究以探索卡那霉素中毒性聋的个体差异的机制。实验选30只家兔分别按给药剂量、时间不同分为两组,观察家兔血清和外淋巴液中卡那霉素的浓度,在相差显微镜下观察耳蜗外毛细胞的形态变化,同时也对肾脏进行了观察。结果:30只家兔的外毛细胞均有不同程度的损害。血清卡那霉素的浓度与外淋巴液中卡那霉素浓度或外毛细胞损害范围之间无相关性。外毛细胞的损害程度与血清中卡那霉素的浓度也无相关性,但与外淋巴液中的卡那霉素浓度则是相关的,即外淋巴液中的卡那霉素浓度越高,外毛细胞的损害范围越广泛。肾损害与血中浓度有关,但
The authors used rabbit experimental studies to explore the mechanism of individual differences in kanamycin-induced deafness. The experiment selected 30 rabbits were divided into two groups according to the dose and time, respectively. The concentrations of kanamycin in rabbit serum and perilymph were observed. The morphological changes of cochlear outer hair cells were observed under phase contrast microscope. The kidneys were observed. Results: The outer hair cells of 30 rabbits all had different degrees of damage. There was no correlation between the concentration of kanamycin in serum and the concentration of kanamycin in perilymph or the range of damage of outer hair cells. The extent of damage to outer hair cells was also unrelated to the concentration of kanamycin in serum but correlated with the concentration of kanamycin in the perilymph, ie, the higher the concentration of kanamycin in the perilymph , The more extensive damage outer hair cells. Kidney damage and blood concentration, but