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目的 :探讨综合治疗对保留喉功能的梨状窝癌的作用。方法 :对梨状窝癌进行保留喉功能治疗的 33例进行回顾性分析。 133例术前分别给予 1周期或 2周期诱导化疗 ;2手术治疗经化疗后的肿瘤切除 ;3术后放射治疗。结果 :化疗后有效率 42 .4%。 3年生存率 5 4.8% ,5年生存率 38.7%。有 2 1例全部恢复了喉功能 ,12例恢复部分喉功能。结论 :以顺铂为主的联合化疗方案对梨状窝癌是安全有效的 ,术前诱导化疗可提高梨状窝癌的手术切除率及喉功能保留率 ,化疗后的肿瘤切除不仅不增加局部复发率 ,而且能提高喉功能的保留率 ,手术后放疗还能提高局部控制率 ,因此综合治疗对梨状窝癌是一种有效的治疗方法
Objective: To investigate the effect of comprehensive treatment on preserving laryngeal function of pear-shaped nest cancer. Methods: Retrospective analysis was performed on 33 cases of preserving laryngeal function in patients with pyriform sinus cancer. 133 cases were given preoperative chemotherapy cycle of 1 or 2 cycles; 2 surgical resection after chemotherapy; 3 postoperative radiotherapy. Results: After chemotherapy, the effective rate was 42.4%. 3-year survival rate of 5 4.8%, 5-year survival rate of 38.7%. In 21 cases, all the laryngeal functions were restored and 12 cases recovered some laryngeal functions. CONCLUSIONS: Cisplatin-based combination chemotherapy is safe and effective for the treatment of infratentorial popliteal carcinoma. Preoperative induction chemotherapy can improve the surgical resection rate and laryngeal function retention rate of the precarious popliteal carcinoma. The tumor excision after chemotherapy not only does not increase the local Recurrence rate, but also to improve the retention rate of laryngeal function, postoperative radiotherapy can improve the local control rate, so the comprehensive treatment of pear-shaped nest cancer is an effective treatment