越来越多的细菌对一线抗生素抗药。许多微生物学家认为,对耳液溢应避免使用一线抗生素,以防产生抗药菌株。为比较防腐剂和抗生素局部应用治疗耳液溢的效果及耐药菌产生的情况,对102只液溢耳进行了8%醋酸铝防腐剂和0.3%庆大霉素滴耳的双盲、随机、前瞻性对比实验。每次5滴,每日3次。治疗9天和21天时进行临床和微生物学评价。结果表明,临床改善率庆大霉素组为68%,醋酸铝组为67%。两组无明显差别。醋酸铝组无抗药菌株产生,而庆大霉素组有12只耳在开始治疗时即有耐药菌,治疗期间有一只耳产生了对庆大霉素耐药的假单胞菌。鉴于醋酸铝和庆大霉素治疗耳液溢的临床效果无差别,为节省花费、避免抗药性和毒性,应 More and more bacteria are resistant to first-line antibiotics. Many microbiologists believe that first-line antibiotics should be avoided for ear fluid spills to prevent the development of drug-resistant strains. To compare the effectiveness of topical application of preservatives and antibiotics in the treatment of ear effusion and the development of drug-resistant bacteria, 102 double-blind, randomized, randomized, controlled trials of 8% aluminum acetate preservatives and 0.3% , Prospective comparative experiment. 5 drops each time, 3 times a day. Clinical and microbiological evaluations were performed at 9 and 21 days of treatment. The results showed that the clinical improvement rate was 68% in the gentamicin group and 67% in the aluminum acetate group. No significant difference between the two groups. Acetate group produced no drug-resistant strains, and gentamicin group had 12 ears at the beginning of treatment that is resistant to bacteria, one ear during treatment produced gentamicin-resistant Pseudomonas. In view of the clinical effect of aluminum acetate and gentamicin treatment of ear effusion no difference, in order to save costs and avoid drug resistance and toxicity should