【摘 要】
：
Acinetobacter baumannii and methicillin-resis-tant Staphylococcus aureus (MRSA) are two prevalent pathogens and have developed high resistant to most antibiotics.Therefore,it is a pressing need to develop a new method to inhibit the spread of drug-resista
【机 构】
：
Shenyang National Laboratory for Materials Science,Key Laboratory for Anisotrotropy and Texture of M
论文部分内容阅读
Acinetobacter baumannii and methicillin-resis-tant Staphylococcus aureus (MRSA) are two prevalent pathogens and have developed high resistant to most antibiotics.Therefore,it is a pressing need to develop a new method to inhibit the spread of drug-resistant bacteria.Copper containing high-entropy alloy (HEA,Alo.4CoCr-CuFeNi) is a new kind of alloy material,which shows extensive antibacterial activity and mechanical properties in our previous research.This study further develops another HEA (CoCrCuFeNi) and evaluates its resistance against gram-negative A.baumannii and Gram-positive MRSA.The antibacterial tests show that the antibacterial rate of the HEA toward both bacteria reached nearly 99％,far better than the traditional copper-bearing 304 stainless steel (304 Cu-SS).The biofilm observation shows that the HEA could not only kill the planktonic bacteria,but also effectively inhibit the formation of biofilm.These data demonstrate that CoCrCuFeNi HEA possesses effective antibacterial and antibiofilm activities,making it a poten-tial candidate for using in hospital,food industry,and domestic kitchens.
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