论文部分内容阅读
目的：观察碘油在肝癌内的动态变化规律及其病理基础。方法：用ＣＴ观察２７例肝癌肝动脉化疗栓塞后不同时间碘油在肿瘤内的动态变化及其与疗效的关系，并对栓塞后切除标本行ＣＴ或软Ｘ线与病理对照研究。结果：碘油在部分肝癌内选择性聚积并持续存留，一般可达２～６月或更长时间，伴肿瘤明显缩小，其病理基础为肿瘤栓后坏死区；碘油在另一部分肝癌虽能选择性聚积但逐渐消失，一般１～２月消失，肿瘤缩小不明显或反增大，其病理基础为肿瘤栓后存活区。碘油在肝癌组织内大部分以颗粒状形式存在于癌细胞浆内。结论：栓塞后定期ＣＴ随访，可判断疗效和确定再次治疗方案。碘油主要存在于癌细胞浆内可能是以碘油作为载体行肝癌肝动脉靶向化／放疗的组织学依据。
Objective: To observe the dynamic changes of lipiodol in hepatocellular carcinoma and its pathological basis. Methods: The dynamic changes of lipiodol in 27 patients with hepatic carcinoma treated with chemoembolization at different time and its relationship with the curative effect were observed by CT. CT and soft X - ray examination and pathology were performed on the resected specimens after embolization. Results: Lipiodol accumulated selectively in some hepatocellular carcinoma and persisted, usually up to 2 ~ 6 months or longer, with the tumor was significantly reduced, the pathological basis for the necrosis of the tumor area after plugging; lipiodol in the other part of the liver cancer though Selective accumulation but gradually disappear, usually disappear from January to February, the tumor was not significantly reduced or anti-increased, the pathological basis for survival after tumor embolization. Lipiodol in the majority of liver cancer in the form of granular particles in the cytoplasm of cancer cells. Conclusion: Regular CT follow-up after embolization can determine the efficacy and determine the re-treatment program. The main presence of iodized oil in the cytoplasm of cancer cells may be based on lipiodol as a carrier for hepatic artery targeting / radiotherapy histology.