目前市面上的口服活轮状病毒疫苗Rotarix和Rota Teq疫苗,在发达国家非常有效。然而,此类疫苗的免疫原性和疗效在一些发展中国家较低。我们以前报道,在肌注免疫动物中细菌表达轮状病毒ΔVP8*亚单位疫苗候选物,具P[8]、P[4]或P[6],能特异性引发高滴度的病毒中和抗体。值得注意的是,发现P[8]ΔVP8*疫苗诱导产生的抗体既中和同型P[8]又中和异型P[4]轮状病毒毒株。为了进 The current oral Rotavirin and Rota Teq oral vaccines against rotavirus are very effective in developed countries. However, the immunogenicity and efficacy of such vaccines are lower in some developing countries. We previously reported that bacterially expressing rotavirus [Delta] VP8 * subunit vaccine candidates, specifically P [8], P [4] or P [6], in bacterially immunized animals specifically elicit high titers of virus neutralization antibody. It is noteworthy that the antibodies induced by the P [8] ΔVP8 * vaccine were found to neutralize both the isotype P [8] and the neutralized P [4] rotavirus strains. To enter