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现已知白细胞介素-2(IL-2)对T细胞、NK细胞、B细胞的功能及干扰素的产生均有作用。本文应用IL-2治疗HBV所致的慢性活动性肝炎(CAH)患者10例,以观察其对HBV复制指标的动态变化和免疫效果。结果显示:HBeAg阴转4例(4/10);IgM-抗HBc阴转3例(3/10),且与HBeAg阴转相一致;在检测HBV-DNA的3例中有2例阴转(2/10)。与对照组相比,其中HBeAg阴转率有显著性差异(P<0.05),但HBsAg无1例阴转。上述结果提示IL-2对HBV的复制确有一定的抑制作用,至于其对HBV确切的清除作用尚需要更多病例作临床验证才能作出比较正确的疗效评价。
It is known that interleukin-2 (IL-2) has an effect on the function of T cells, NK cells, B cells and the production of interferon. In this paper, 10 cases of chronic active hepatitis (CAH) caused by HBV were treated with IL-2 in order to observe its dynamic change and immune effect on HBV replication. The results showed that: 4 cases (4/10) of negative HBeAg; 3 cases of negative IgM-anti-HBc (3/10), consistent with negative conversion of HBeAg; 2 cases of negative (2/10). Compared with the control group, the negative rate of HBeAg was significantly different (P <0.05), but none of HBsAg was negative. The above results suggest that IL-2 has a certain inhibitory effect on the replication of HBV, and its exact elimination of HBV still requires more cases for clinical validation to make a more correct evaluation of the efficacy.