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目的探讨妊娠高血压综合征 (简称妊高征 )患者尿 N-乙酰 β-D氨基葡萄糖苷酶 ( NAG)及尿 β2 -微球蛋白 ( β2 -MG)的变化规律及临床意义。方法对 6 4例妊高征患者 (轻、中度 35例 ,重度 31例 )与正常孕妇组 ( 38例 )尿 NAG及β2 -MG进行比较 ,并进行各型妊高征组之间尿 NAG、β2 -MG的比较。结果妊高征组与正常孕妇组对照 ,尿 NAG及β2 -MG升高有极显著差异 ( P<0 .0 1)。而且重度妊高征组较轻、中度妊高征组尿 NAG、β2 -MG升高有显著性差异 ( P<0 .0 1,P<0 .0 5 )。结论尿 NAG及β2 -MG是妊高征早期肾小管功能损害的敏感指标 ,且能反映肾小管受损程度
Objective To investigate the changes and clinical significance of urinary N-acetylglucosaminidase (NAG) and urinary β2-microglobulin (β2-MG) in patients with pregnancy induced hypertension (PIH). Methods The urinary NAG and β2-MG in 64 cases of PIH (mild and moderate 35 cases and severe 31 cases) and normal pregnant women (38 cases) were compared and urine NAG , Β2-MG comparison. Results There was a significant difference (P <0.01) in urine NAG and β2-MG between control group and normal pregnant women. And severe PIH group was mild, moderate PIH group urinary NAG, β2-MG increased significantly (P <0.01, P <0.05). Conclusions Urinary NAG and β2-MG are sensitive indicators of early renal tubular dysfunction and can reflect the degree of renal tubular damage