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目的:研究齐墩果酸自微乳在大鼠胃肠道的吸收动力学特征。方法:采用大鼠在体胃肠道吸收实验,高效液相色谱法测定药物浓度,根据药物在胃肠道中的减少量来确定药物的吸收。结果:在大鼠胃部,齐墩果酸微乳2h的吸收百分率为10.15%;在小肠中齐墩果酸微乳与胶束的吸收速率常数分别为0.0901/h和0.0486/h,肠道最佳吸收部位依次为十二指肠、回肠、空肠和结肠。结论:自微乳给药系统对齐墩果酸在大鼠胃肠道的吸收有明显的促进作用,显著提高了齐墩果酸的生物利用度。
Objective: To study the absorption kinetics of oleanolic acid self-microemulsion in rat gastrointestinal tract. Methods: The rat gastrointestinal absorption test in vivo, high performance liquid chromatography determination of drug concentration, according to the drug in the gastrointestinal tract to determine the reduction of drug absorption. RESULTS: The absorption percentage of oleanolic acid microemulsion was 10.15% in the stomach of rats and that of oleanolic acid microemulsion and micelle in the small intestine were 0.0901 / h and 0.0486 / h, respectively The best absorption sites followed by the duodenum, ileum, jejunum and colon. CONCLUSION: Oleanolic acid can significantly enhance the absorption of gastrointestinal tract in rats and improve the bioavailability of oleanolic acid significantly.