论文部分内容阅读
目的 :探索遗传和环境因素对胰岛素敏感性作用的大小。方法 :采用稳态模型 (homeostasismodelassess ment ,HOMA)的对数来衡量 2 4 9对双生子的胰岛素敏感性 ,其中同卵双生子 1 6 9对 ,异卵双生子 80对。将影响胰岛素敏感性的因素分成加性遗传方差 (A)、显性遗传方差 (D)、共同环境方差 (C)和个体特殊环境方差 (E) 4个部分 ,用最大似然法拟合单变量遗传模型 ,同时考虑年龄和性别对胰岛素敏感性遗传度的影响。结果 :年龄对胰岛素敏感性遗传度的影响没有显著性 (χ2 =1 .85 1 ,P =0 .6 0 4 ) ,最适模型是AE模型 ,男性的遗传度为 35 % ,女性的遗传度为 4 6 %。结论 :本双生子人群遗传方差在胰岛素敏感性方差中所占的比重男性为 35 % ,女性为 4 6 %。
Purpose: To explore the role of genetic and environmental factors on insulin sensitivity. Methods: The insulin sensitivity of 299 pairs of twins was measured by logarithm of homeostasis model dissimilarity (HOMA), including 169 pairs of identical twins and 80 pairs of fraternal twins. The factors influencing insulin sensitivity were divided into four parts: additive genetic variance (A), dominant genetic variance (D), common environmental variance (C) and individual specific environmental variance (E) Variable genetic models, taking into account the influence of age and gender on the heritability of insulin sensitivity. Results: The effect of age on the heritability of insulin sensitivity was not significant (χ2 = 1.851, P = 0.060). The optimal model was AE model. The heritability of males was 35%. The heritability of females Is 46%. CONCLUSIONS: The genetic variance of the twins in the proportion of insulin sensitivity variance is 35% for males and 46% for females.