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应用放射免疫分析法检测正常对照组２４例及肠易综合征组（ＩＢＳ）２６例受检者血浆及乙状结肠粘膜中胆囊收缩素（ＣＣＫ）和胃动素（ＭＯＴ）的含量，旨在探讨ＩＢＳ患者血浆及乙状结肠粘膜中ＣＣＫ和ＭＯＴ有无变化，以及它们在ＩＢＳ疾病过程中的可能作用和临床意义。结果：ＩＢＳ组血浆中ＣＣＫ、ＭＯＴ的含量明显高于正常对照组（Ｐ＜０．０５）；乙状结肠粘膜中ＣＣＫ的含量两组无显著差别（Ｐ＞０．２），ＭＯＴ的含量两组均为零。提示血浆中ＣＣＫ和ＭＯＴ可能在ＩＢＳ的疾病过程中起有一定作用，建议在临床实验诊断中验证它们作为ＩＢＳ诊断标志的可能性。
Radioimmunoassay was used to detect the contents of CCK and MOT in plasma and in the sigmoid colon mucosa of 24 healthy volunteers and 26 IBS patients. CCK and MOT in patients with plasma and sigmoid mucosa have no change, and their possible role in IBS disease process and clinical significance. Results: The content of CCK and MOT in plasma of IBS group was significantly higher than that of normal control group (P <0.05). CCK content in sigmoid colon mucosa showed no significant difference (P> 0.2) Zero. Suggesting that CCK and MOT in plasma may play a role in the pathogenesis of IBS. It is suggested that they should be validated in clinical laboratory diagnosis as potential markers of IBS diagnosis.