论文部分内容阅读
目的探讨博莱霉素(BLM)致肺纤维化(PF)的影像学表现与血管内皮细胞(EC)病理学间的关系。方法健康SD大鼠随机分为实验组和对照组各20只,实验组大鼠制作BLM损伤PF模型,分别在第3、7、14、28天(各5只)行HRCT扫描后、检测外周血中vWf水平、肺血管造影及制作电镜标本。对照组方法同实验组。结果实验组大鼠外周血vWf水平均高于对照组(P<0.05),以3天组为著(P<0.01)。磨玻璃样影和实变影主要见于3、7天组,支气管血管束增粗见于7天以后。蜂窝肺则见于14、28天组,以28天组为著。实验7、14天组肺动脉远端纹理明显增粗,分支增多,血管周围显示模糊,28天组肺动脉远端纹理纤细,分支减少,近端肺动脉增粗。实验3天组EC变性、坏死,部分区域见EC增生,7、14天组均可见新生毛细血管,分布于靠近基底膜的纤维化区域。结论HRCT能较准确反应PF的病理变化及病程,EC损伤与PF发生、发展过程密切相关。
Objective To investigate the relationship between the imaging findings of pulmonary fibrosis (PF) and the pathology of vascular endothelial cells (EC) caused by bleomycin (BLM). Methods Healthy Sprague-Dawley rats were randomly divided into experimental group and control group, 20 rats in each group. The rats in experimental group were made PF model of BLM lesion. HRCT scan was performed on the 3rd, 7th, 14th and 28th days (5 rats each) VWf levels in blood, pulmonary angiography and the production of electron microscopy specimens. Control group method with the experimental group. Results The levels of vWf in experimental group were higher than those in control group (P <0.05), and were significantly higher in 3-day group (P <0.01). Glass-like shadows and real shadows were mainly seen in the 3,7-day group, which were seen after 7 days of thickening of the bronchovascular bundle. Honeycomb lung was seen in 14,28 days group, with 28 days for the group. On day 7 and day 14, the distal pulmonary arteries were significantly thicker, with more branches and vague periphery. The distal pulmonary arteries were slender, with fewer branches and thicker proximal pulmonary arteries in 28 days. Experimental 3 days group EC degeneration, necrosis, EC see some areas of proliferation, 7,14 days were visible capillary capillaries, located in the fibrosis near the basement membrane area. Conclusion HRCT can accurately reflect the pathological changes and course of PF. EC injury is closely related to the occurrence and development of PF.