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羧基末端结合有糖基化磷脂酰肌醇(GPI)结构的膜蛋白,称为GPI锚定蛋白(glycosylphosphatidy-linositol-anchored protein);它们功能广泛,涉及细胞识别、生长、分化和程序性死亡等重要生命过程,与许多疾病有着一定的联系。人体内水解GPI锚定蛋白中的肌醇磷酸酯键的只有糖基化磷脂酰肌醇特异性磷脂酶D(glycosylphosphatidy-linositol spe-cific phospholipaseD GPI-PLD)。本文概述了近年来有关GPI锚定蛋白的研究状况,包括它的结构、组成、功能和水解酶GPI-PLD,GPI锚定蛋白与白血病的发生、发展及治疗等的相关性研究。
Membrane proteins with a glycosylphosphatidylinositol (GPI) structure attached to the carboxy terminus are termed GPI-anchored proteins (GPI-anchored proteins); they function extensively and are involved in cell recognition, growth, differentiation and programmed death Important life processes, and many diseases have a certain connection. Only glycosylphosphatidy-linositol spe-cific phospholipase D GPI-PLD is hydrolyzed in vivo by inositol phosphate linkages in GPI-anchored proteins. This article summarizes the research status of GPI-anchored protein in recent years, including its structure, composition, function and the correlation between GPI-PLD, GPI-anchored protein and the occurrence, development and treatment of leukemia.