四十年来胰腺癌的发生率增加了三倍,仅次于肺、结肠、前列腺癌,占癌症第四位死因,5年存活率仅1-2%。发病率增高的原因不明,存活率低与本病的早期诊断与治疗困难有关。发现本病时仅很小部分能行根治术,此时仅15%限于胰腺(Ⅰ期);20%有区域淋巴结转移(Ⅱ期);65%有肝转移(Ⅲ期)。放疗也有很多困难:①胰腺部位深且邻近许多重要器官限制了照射量;②胰腺癌是“相对放射抵抗”的病理类型。 Fermi国家加速器实验室在从1976年开始的研究中收治了50例胰腺癌病人。38例最少随访11个月,其中6例在治疗时已有远处转移,1例后来证实为网织细胞肉瘤均不予分析。病人平均年龄60岁(45-77岁),均行剖腹探查取病理及胆道捷经手 The incidence of pancreatic cancer has tripled in the past 40 years, second only to lung, colon, and prostate cancer, accounting for the fourth cause of cancer death. The 5-year survival rate is only 1-2%. The cause of the increase in the incidence rate is unknown, and the low survival rate is related to the early diagnosis and treatment difficulties of this disease. Only a small part of the disease was found to undergo radical surgery. Only 15% of this time was limited to the pancreas (stage I); 20% had regional lymph node metastasis (stage II); 65% had hepatic metastasis (stage III). Radiotherapy also has many difficulties: 1 The pancreas is deep and close to many important organs limit the exposure; 2 Pancreatic cancer is a “relative radiation resistance” pathological type. The Fermi National Accelerator Laboratory received 50 patients with pancreatic cancer in a study that began in 1976. Of the 38 patients who had a minimum follow-up of 11 months, 6 patients had distant metastases at the time of treatment, and 1 patient who had later been confirmed to have reticulocyte sarcoma were not analyzed. The average age of the patients was 60 years old (45-77 years old). All patients underwent laparotomy for pathology and biliary tract