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目的掌握绍兴市肺结核患者耐药情况,为预防控制肺结核提供依据。方法对2010—2013年6月在绍兴市结核病定点医院就诊的涂阳肺结核患者痰标本分离株进行菌型鉴定,用药敏罗氏培养基进行药物敏感性试验,分析肺结核患者的耐药情况。结果在607份痰培养阳性标本中,总耐药率为20.26%,耐多药(MDRTB)率12.85%,耐药率由高到低依次为INH、RFP、SM和EMB;初治总耐药率13.09%,耐多药率5.73%;复治总耐药率为50.00%,耐多药率42.37%。结论绍兴市结核分枝杆菌的总耐药率与全国平均水平相当,但复治病例耐多药率仍较高。
Objective To master the drug resistance of patients with pulmonary tuberculosis in Shaoxing City and provide evidence for prevention and control of pulmonary tuberculosis. Methods The sputum samples of smear-positive pulmonary tuberculosis patients from 2010 to 2013 in designated hospitals of TB in Shaoxing were tested for their mycobacterial type. Drug susceptibility tests were performed on drug sensitive Roche medium and the drug resistance of patients with pulmonary tuberculosis was analyzed. Results Among the 607 sputum positive specimens, the total resistance rate was 20.26%, the MDRTB rate was 12.85%, and the resistance rates were INH, RFP, SM and EMB, Rate of 13.09%, MDR rate of 5.73%; retreatment total resistance rate was 50.00%, MDR rate of 42.37%. Conclusion The total drug resistance rate of Mycobacterium tuberculosis in Shaoxing is equal to the national average level, but the rate of multidrug-resistant in retreatment cases is still high.