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目的探讨GnRH-a对子宫内膜异位症患者术后的疗效及IL-8水平的影响。方法 100例子宫内膜异位症术后患者随机分为两组,对照组50例,使用孕三烯酮治疗,观察组50例,使用GnRH-a治疗,对比2组患者临床疗效、复发率、不良反应及IL-8水平。结果观察组临床疗效优于对照组,复发率低于对照组,两组间比较差异均有统计学意义(P<0.05)。不良反应观察组低于对照组,IL-8水平观察组低于对照组,两组间比较差异均有统计学意义(P<0.05)。结论子宫内膜异位症术后GnRH-a治疗较孕三烯酮临床疗效显著,不良反应小,并可以有效改善治疗后IL-8水平。
Objective To investigate the effect of GnRH-a on postoperative efficacy and IL-8 level in patients with endometriosis. Methods 100 cases of endometriosis patients were randomly divided into two groups, the control group of 50 cases, the use of gestrinone treatment, observation group of 50 cases, the use of GnRH-a treatment, the two groups of patients with clinical efficacy, recurrence rate , Adverse reactions and IL-8 levels. Results The clinical curative effect of the observation group was better than that of the control group, the recurrence rate was lower than that of the control group, with significant difference between the two groups (P <0.05). Adverse reaction observation group was lower than the control group, IL-8 level observation group was lower than the control group, the difference between the two groups were statistically significant (P <0.05). Conclusion The postoperative GnRH-a treatment of endometriosis is more effective than gestrinone in clinical efficacy and adverse reactions, and can effectively improve the level of IL-8 after treatment.