,hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cel

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Dear Editor,Endocytosis is a crucial process employed by cells to intemalize nutrients and tumover membrane components and is essential for many functions,including nutrient uptake,signal transduction,cytokinesis,morphogenesis,cell adhesion and migration.Endocytosis is classified as clathrin-dependent endocytosis (CDE) or clathrin-independent endocytosis (CIE) according to its dependence on clathrin.Several different CIE pathways have been proposed,including caveolin-dependent endocytosis,fiotillin-dependent endocytosis,the clathrin-independent carrier pathway,ARF6-dependent endocytosis,phagocytosis,macropinocytosis,the IL2Rβ pathway (Doherty and McMahon,2009),the newly identified fast endophilin-mediated endocytosis pathway (Boucrot et al.,2015) and the EGFR-NCE pathway (Caldieri et al.,2017).
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