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目的 分析不同化疗方案联合放疗治疗中晚期鼻咽癌的临床效果.方法 选取我院2014G6-2016G3收治的90例中晚期鼻咽癌的患者作为研究对象,其中奈达铂组、卡铂组和奥沙利铂组各30例,奈达铂组给予奈达铂联合氟尿嘧啶,卡铂组给予卡铂联合氟尿嘧啶,奥沙利铂组给予奥沙利铂联合氟尿嘧啶.比较三组患者的治疗效果及不良反应(骨髓抑制、胃肠道反应、口腔炎)发生率.结果 奈达铂组有效率为(9333%),卡铂组有效率为(7333%),奥沙利铂组有效率为(8666%),奈达铂组有效率明显优于卡铂组和奥沙利铂组(P<005),差异显著,具有统计学意义,卡铂组和奥沙利铂组对比差异不显著(P>005),无统计学意义.奈达铂组不良反应发生率显著低于卡铂组,卡铂组与奥沙利铂组对比无显著差异(P>005),无统计学意义.结论 采取不同铂类+5-氟尿嘧啶化疗联合放疗治疗中晚期鼻咽癌均有显著的效果,而奈达铂联合氟尿嘧啶的有效率较为显著,不良反应发生率也较低,值得临床推广使用.
Objective To analyze the clinical effects of different chemotherapy regimens combined with radiotherapy in the treatment of advanced nasopharyngeal carcinoma.Methods Ninety patients with advanced nasopharyngeal carcinoma treated with 2014G6-2016G3 in our hospital were enrolled in this study. Nedaplatin, carboplatin, 30 cases in the group of sullivan, nedaplatin combined with 5-fluorouracil in nedaplatin group, 6 cases of carboplatin and 5-fluorouracil in carboplatin group, and oxaliplatin combined with 5-fluorouracil in oxaliplatin group.Compared the curative effect and bad (9333%) in the nedaplatin group, (7333%) in the carboplatin group, and (8666) in the oxaliplatin group %), The efficiency of nedaplatin group was significantly better than carboplatin group and oxaliplatin group (P <005), the difference was significant, with statistical significance, carboplatin group and oxaliplatin group, the difference was not significant (P > 005), but there was no statistical significance.The incidence of adverse reactions in nedaplatin group was significantly lower than that in carboplatin group (P> 0.05), but there was no significant difference between carboplatin group and oxaliplatin group Different platinum + 5- fluorouracil chemotherapy combined with radiotherapy in the treatment of advanced nasopharyngeal carcinoma have a significant effect, and nedaplatin Co-fluorouracil significantly more efficient, lower incidence of adverse reactions, it is worthy of clinical use.