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目的 用FAIR技术评价难治性及非难治性颞叶癫痫患者发作间期rCBF异常的模式是否不同。方法 9例难治性颞叶癫痫、21例非难治性颞叶癫痫患者及13名正常志愿者,测量其双侧大脑半球及双侧内侧颞叶的rCBF,并计算不对称指数(AI)。结果 难治性及非难治性癫痫患者大脑半球AI值与正常对照组之间有统计学差异(P值分别为0.012 和0.029);难治性颞叶癫痫患者内侧颞叶AI值与正常对照组之间无统计学差异(P=0.102),而非难治性癫痫患者与正常对照组之间有统计学差异(P=0.049)。结论 难治性和非难治性颞叶癫痫患者发作间期rCBF异常的模式有所不同,虽然均可出现较广泛的rCBF异常,但难治性癫痫更倾向于出现双侧内侧颞叶低灌注,这可为判断预后提供帮助。
Objective To evaluate whether the patterns of rCBF abnormalities in interictal interictal patients with refractory and non-refractory temporal lobe epilepsy were evaluated by FAIR technique. Methods 9 cases of intractable temporal lobe epilepsy, 21 cases of non-refractory temporal lobe epilepsy and 13 normal volunteers were enrolled in this study. The rCBF was measured in bilateral hemispheric and bilateral medial temporal lobes and the asymmetry index (AI) was calculated. Results There was a significant difference (P = 0.012 and 0.029, respectively) between cerebral hemispheric AI values in patients with refractory and non-refractory epilepsy; the value of medial temporal lobe AI in patients with refractory temporal lobe epilepsy was significantly lower than that in the control group (P = 0.102), but there was a significant difference between non-refractory epilepsy group and normal control group (P = 0.049). Conclusion The patterns of rCBF abnormalities in patients with intractable and non-refractory temporal lobe epilepsy are different. Although rCBF abnormalities may occur in a wide range of patients, refractory epilepsy is more prone to bilateral medial temporal lobe hypoperfusion, This can help to determine the prognosis.