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质子作为一种高传能线密度(LET)的辐射,具有能量沉积与局部剂量远大于低LET辐射(如X射线、γ射线和电子束等)的特点,通过物质时有完全不同的径迹结构,能够更有效的诱发DNA发生双链断裂,产生更多的不能修复性损伤,引起细胞的转化和死亡以及癌的发生等较高的相对生物效应(RBE)。在DNA分子水平上研究质子致生物损伤的机理,深入了解其辐射特点及危害程度,并研究相应的防护途径十分重要,其研究结果可为太空辐射环境中质子辐射的危害评估与防护以及
As a kind of LET radiation, proton has the characteristics of energy deposition and local dose far greater than those of low LET radiation (such as X-ray, γ-ray and electron beam). There are totally different tracks Structure, which can induce higher double-strand breaks of DNA more efficiently, produce more irreversible damage, cause higher relative biological effects (RBE) such as cell transformation and death, and carcinogenesis. It is very important to study the mechanism of proton-induced biological damage at the DNA molecular level, to understand its radiation characteristics and degree of harm, and to study the corresponding protective ways. The results of this study can be used to evaluate and protect the proton radiation in space radiation environment,