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目的:考察常温下(25℃)6 h内注射用苯唑西林钠在5％葡萄糖注射液、10％葡萄糖注射液、葡萄糖氯化钠注射液和0．9％氯化钠注射液4种输液中的稳定性。方法:用HPLC法测定配伍后苯唑西林钠的含量变化,并考察配伍液的外观和pH变化。结果:苯唑西林钠在0．9％氯化钠注射液和5％葡萄糖注射液中有良好的稳定性,在10％葡萄糖注射液和葡萄糖氯化钠注射液中稳定性较差。结论:注射用苯唑西林钠与输液配伍时应首选0．9％氯化钠注射液,与5％葡萄糖注射液可配伍,但宜在3 h内滴完,与10％葡萄糖注射液和葡萄糖氯化钠注射液配伍应尽量减少。
OBJECTIVE: To investigate the effects of oxacillin sodium injection in 5% dextrose injection, 10% glucose injection, glucose and sodium chloride injection and 0.9% sodium chloride injection 6 h at room temperature (25 ℃) In the stability. Methods: The content of oxacillin sodium was determined by HPLC. The appearance and pH of the compatibility solution were also investigated. Results: Oxacillin sodium had good stability in 0.9% sodium chloride injection and 5% glucose injection, and its stability was poor in 10% glucose injection and glucose and sodium chloride injection. Conclusion: The combination of oxacillin sodium and infusion should be the first choice of 0.9% sodium chloride injection, and 5% glucose injection compatibility, but should be drip finished within 3 h, and 10% glucose injection and glucose Sodium chloride injection should be minimized.