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目的探讨黄体期添加小剂量雌激素对体外受精-胚胎移植(IVF-ET)胚胎种植率和临床妊娠率的影响。方法回顾性分析429个长方案控制性超促排卵(COH)IVF-ET周期的治疗结果,根据其黄体期支持用药情况分为两组:A组:231个周期,单用黄体酮(P)60mg/d;B组:198个周期,P60mg/d加戊酸雌二醇(补佳乐)4~8mg/d进行黄体支持。结果①429个治疗周期中,各组患者的年龄、不孕年限、移植胚胎数相比,差异均无显著性(P>0.05);②两组的妊娠率和胚胎种植率无显著性差异(P>0.05)。结论黄体期补充小剂量E2不能改善IVF-ET的妊娠率及胚胎种植率。
Objective To investigate the effect of low dose estrogen addition during luteal phase on embryo implantation rate and clinical pregnancy rate of IVF-ET. Methods The treatment outcome of 429 long-term controlled ovarian hyperstimulation (COH) cycles of IVF-ET was retrospectively analyzed. The patients were divided into two groups according to their supportive use of luteal phase: group A: 231 cycles with progesterone alone (P) 60mg / d; Group B: 198 cycles, P60mg / d plus estradiol valerate (norepinephrine) 4 ~ 8mg / d for luteal support. Results ① There were no significant differences in age, duration of infertility, and the number of embryos transferred among the 429 treatment cycles (P> 0.05). There was no significant difference in pregnancy rate and embryo implantation rate between the two groups (P > 0.05). Conclusion Luteal phase with low dose of E2 can not improve the IVF-ET pregnancy rate and embryo implantation rate.