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目的:观察中西医结合治疗儿童咳嗽变异性哮喘(CVA)的临床疗效。方法:选取儿童CVA患儿88例,随机分为中西医组和西医组各44例。2组患儿均根据全球哮喘防治创议制定的治疗方案进行治疗。西医组加用匹多莫德口服液治疗。中西医组在西医组治疗方案的基础上加用玉屏风颗粒治疗。2组患者疗程均为8周。观察评估2组患儿临床疗效,治疗结束后随访1年观察咳嗽复发例数、复发率及典型哮喘转化例数及转化率。结果:治疗8周后,中西医组患儿临床总有效率95.45%高于西医组79.55%,差异有统计学意义(P<0.05);随访1年,中西医组42例患儿中咳嗽复发8例,复发率19.05%;典型哮喘转化4例及转化率9.52%。中西医组35例患儿中咳嗽复发15例,复发率42.86%;典型哮喘转化1例及转化率为2.86%。中西医组患儿咳嗽复发率低于西医组,差异有统计学意义(P<0.05)。2组患儿典型哮喘转化率比较,差异无统计学意义(P>0.05)。结论:中西医结合治疗儿童CVA的疗效优于单纯西医治疗,能改善其咳嗽症状,减少复发,具有治疗与预防儿童CVA病情复发的双重效应。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of children with cough variant asthma (CVA). Methods: A total of 88 children with CVA were enrolled in this study. They were randomly divided into two groups (44 in each). The two groups of children were treated according to the treatment plan developed by the global asthma prevention and treatment initiative. Western medicine group with pidotimod oral solution. Western medicine group in the Western medicine group based on the treatment program plus Yupingfeng particles treatment. Two groups of patients were treated for 8 weeks. The clinical efficacy of the two groups were observed and evaluated. The number of cough recurrences, the recurrence rate, the number of typical asthma conversion cases and the conversion rate were observed one year after the end of treatment. Results: After 8 weeks of treatment, the total clinical effective rate of Chinese and western medicine group was 95.45% higher than that of Western medicine group (79.55%), the difference was statistically significant (P <0.05); Follow-up of 1 year, 42 cases of Chinese and Western medicine group cough recurrence 8 cases, the recurrence rate was 19.05%; 4 cases of typical asthma conversion and conversion rate of 9.52%. In the 35 cases of Chinese and western medicine group cough recurrence in 15 cases, the recurrence rate was 42.86%; 1 case of typical asthma conversion and conversion rate of 2.86%. The recurrence rate of cough in the Western medicine group was lower than that in the western medicine group, the difference was statistically significant (P <0.05). There was no significant difference in the typical asthma conversion rates between the two groups (P> 0.05). Conclusion: The effect of traditional Chinese and western medicine in treating CVA in children is better than that of western medicine alone. It can improve its cough symptoms and reduce recurrence. It has the dual effect of treating and preventing recurrence of CVA in children.