Microwave radiation was applied to the detection of metamizoie sodium by cyclic voltammetry.The electrochemical characteristics of metamizoie sodium were studied by cyclic voltammetry at GC electrode under microwave radiation and a considerable current enhancement was observed for metamizoie sodium in aqueous 0.05 mol/L H_2SO_4.Under the optional conditions,metamizoie sodium was determined in the absence and presence of microwave activation.In the absence of microwave activation cyclic voltammogram of metamizoie sodium shows good linear relationship in a concentration range of 8.0×10~(-5)—1.0×10~(-3) mol/L in aqueous 0.05 mol/L H_2SO_4 with a detection limit of 6.75×10~(-6) mol/L(S/N=3) and the equation of linear regression is I_p=12.973c-0.1905(R~2=0.9996,n=6);in the presence of 80 W microwave activation cyclic voltammogram of metamizoie sodiumin shows good linear relationship in a concentration range of 4.0×10~(-5)—1.0×10~(-3) mol/L in aqueous 0.05 mol/L H_2SO_4 with a detection limit of 4.41×10~(-6)mol/L(S/N=3) and the equation of linear regression is I_p=25.107c-0.1193(R~2=0.9973,n=7).The current in the presence of 80 W microwave activation increases to about 2 orders of magnitude compared with that in the absence of microwave activation.The proposed method in the presence of microwave activation showed high selectivity and sensitivity,and the sampling of the disposal method is simple.The method was verified by the determination of Metamizoie Sodium tablet with satisfactory results. Microwave radiation was applied to the detection of metamizoie sodium by cyclic voltammetry. The electrochemical characteristics of metamizoie sodium were studied by cyclic voltammetry at GC electrode under microwave radiation and a substantial current enhancement was observed for metamizoie sodium in aqueous 0.05 mol / L H 2 SO_4.Under the optional conditions, metamizoie sodium was determined in the absence and presence of microwave activation. the absence of microwave activation cyclic voltammogram of metamizoie sodium shows good linear relationship in a concentration range of 8.0 × 10 -5 -1.0 × 10 ~ (-3) mol / L in aqueous 0.05 mol / L H 2 SO 4 with a detection limit of 6.75 × 10 -6 mol / L (S / N = 3) and the equation of linear regression is I_p = 12.973 c-0.1905 (R ~ 2 = 0.9996, n = 6); in the presence of 80 W microwave activation cyclic voltammogram of metamizoie sodiumin shows good linear relationship in a concentration range of 4.0 × 10 -5 -1.0 × 10 -3 ) mol / L in aqueous 0.05 mol / L H 2 SO 4 with a detec tion limit of 4.41 × 10 ~ (-6) mol / L (S / N = 3) and the equation of linear regression is I_p = 25.107c-0.1193 (R ~ 2 = 0.9973, n = 7) presence of 80 W microwave activation increases to about 2 orders of magnitude compared with that in the absence of microwave activation. proposed method in the presence of microwave activation showed high selectivity and sensitivity, and the sampling of the disposal method is simple. method was verified by the determination of Metamizoie Sodium tablet with satisfactory results.