白细胞介素1(IL-1)是机体对微生物的侵袭而作出反应的重要调节因子之一,它所具有的多种功能中主要为炎症介质作用。与其他种属一样,两种生物化学完全不同而在结构上相关的IL-1分子已在人体中获得克隆,即IL-1-α和IL-1-β。每个人的IL-1由不同基因编码,但两者均在第二条染色体上。在人IL-1-α(hIL-1-α)与IL-1-β(hIL-1-β)间只有26％的氨基酸序列为同源性,相反,hIL-1-β有74％氨基酸序列与兔IL-1 Interleukin-1 (IL-1) is one of the important regulators of the body’s response to microbial invasion, with many of its functions being primarily inflammatory mediators. Like other species, two biochemically distinct and structurally related IL-1 molecules have been cloned in humans, IL-1-α and IL-1-β. Each person’s IL-1 is encoded by a different gene, but both are on the second chromosome. Only 26% of the amino acid sequences are homologous between human IL-1-α (hIL-1-α) and IL-1-β (hIL-1-β), whereas hIL- Sequence and rabbit IL-1