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目的:探讨环氧化酶-2(COX-2)和表皮生长因子受体2(HER-2)在非小细胞肺癌(NSCLC)组织中的表达及其临床意义。方法:应用免疫组织化学法检测54例NSCLC、15例癌旁增生肺组织和10例正常肺组织中COX-2和HER-2蛋白的表达。结果:NSCLC组织中COX-2和HER-2蛋白阳性率分别为75.9%(41/54)和40.7%(22/54),癌旁肺组织、正常肺组织相比,差异均有统计学意义,P<0.001。COX-2蛋白表达与患者吸烟、组织学分级、TNM分期以及淋巴结转移均密切相关,P<0.05。而HER-2蛋白表达与NSCLC患者的病理类型、组织学分级、TNM分期和淋巴结转移密切相关,P<0.05。在54例NSCLC组织中,COX-2和HER-2蛋白表达之间呈显著正相关,r=0.433,P=0.001。结论:COX-2和HER-2在NSCLC中呈高表达,两者可能协同促进NSCLC的发生、发展以及侵袭和转移。
Objective: To investigate the expression and clinical significance of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor 2 (HER-2) in non-small cell lung cancer (NSCLC) Methods: The expressions of COX-2 and HER-2 protein in 54 cases of NSCLC, 15 cases of paracancerous hyperplasia lung tissues and 10 cases of normal lung tissues were detected by immunohistochemistry. Results: The positive rates of COX-2 and HER-2 protein in NSCLC tissues were 75.9% (41/54) and 40.7% (22/54), respectively. There was significant difference between adjacent lung cancer tissues and normal lung tissues , P <0.001. COX-2 protein expression was closely related to smoking, histological grade, TNM stage and lymph node metastasis, P <0.05. However, HER-2 protein expression was closely related to pathological type, histological grade, TNM stage and lymph node metastasis in NSCLC patients (P <0.05). In 54 NSCLC tissues, there was a significant positive correlation between the expression of COX-2 and HER-2 protein (r = 0.433, P = 0.001). Conclusion: COX-2 and HER-2 are highly expressed in NSCLC, both of which may synergistically promote the occurrence, development, invasion and metastasis of NSCLC.