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非黑素细胞性皮损,例如Paget病偶然会在临床和组织学上与原发性浅表扩散性恶黑相混淆,尤其是在原位早期.这常常是由于Paget病的瘤细胞在表皮内扩散生长并产生较多的黑素颗粒,或者是由于帕哲样原位恶黑很少产生或不产生黑素颗粒而造成的.为了有助于这两种病的鉴别诊断,作者比较了这二类肿瘤组织中S100蛋白的含量和对PAS及粘蛋白卡红染色的反应性,病例是用随机方法取自1976～1983年间外科常规病理保存的蜡块材料.其中9例乳房Paget病,10例外阴Paget病和10例浅表扩散性原位恶黑.S100蛋白的免疫组化是用过氧化酶-抗过氧化酶技术和兔抗牛脑S100蛋白的抗血清法.所有标本均用1/
Non-melanocytic lesions, such as Paget’s disease, occasionally become clinically and histologically confused with primary superficial diffusive nausea, especially early in situ. This is often due to the presence of Paget’s neoplastic cells in the epidermis. In-diffusion grows and produces more melanin granules, or is caused by the infrequent production or inability of melanin granules produced by in-situ dark blacks. In order to facilitate the differential diagnosis of these two diseases, the authors compared The content of S100 protein in these two types of tumor tissues and their reactivity to PAS and mucin Cartilage staining. Cases were randomly selected from paraffin-embedded paraffin-embedded materials from 1976 to 1983. Among them, 9 cases of breast Paget’s disease, 10 exceptions for Paget’s disease and 10 cases of superficial diffuse in situ nausea. Immunohistochemistry of S100 protein was performed using the peroxidase-anti-peroxidase technique and the rabbit anti-bovine brain S100 protein antiserum. All specimens were used. 1/