益气温阳活血方治疗慢性肺源性心脏病的临床价值

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目的:探讨益气温阳活血方治疗慢性肺源性心脏病的临床价值。方法:选取2017年12月至2019年7月上海市第十人民医院诊治的慢性肺源性心脏病患者作为研究对象,60例慢性肺源性心脏病患者采用随机数字表法分为两组,每组各30例。对照组给予常规治疗,观察组在此基础上加用国医大师颜德馨教授的益气温阳活血方治疗,连续用药1个月,比较观察治疗后在左心室射血分数(LVEF)、B型脑利钠肽(BNP)、第1秒用力呼气容积占用力肺活量百分比(FEVn 1/FVC)、日常生活能力评定量表等重要心肺指标的疗效指标及在肝肾功能等方面安全性评价。n 结果:观察组治疗后LVEF比对照组升高[(58.83 ± 3.16)%比(52.80 ± 4.23)%],BNP比对照组降低[(205.60 ± 29.51)ng/L比(218.50 ± 25.64)ng/L],FEVn 1/FVC比对照组升高[(89.13 ± 3.44)%比(76.90 ± 3.79)%],日常生活能力评定量表评分较对照组升高[(79.27 ± 5.71)分比(70.30 ± 5.49)分],差异有统计学意义(n P<0.05)。肝肾功能、凝血功能、心电图等观察组治疗前后未见明显变化,安全性较高。n 结论:在常规西医治疗基础上加用益气温阳活血方治疗慢性肺源性心脏病,以益气活血为治疗原则,从“心肺同治”角度,能安全有效地改善患者心肺功能,减轻其心脏负担,提高患者生命质量,为肺源性心脏病治疗提供新的治疗方法及策略。“,”Objective:To investigate the clinical value of Yiqi Wenyang Huoxue Recipe in the treatment of chronic cor pulmonale.Methods:Sixty patients with clinical criteria of chronic pulmonary heart disease were collected and divided into treatment group and control group according to the random numbers table, of which 30 cases were in the treatment group and 30 cases were in the control group. In the treatment group, 30 cases were treated with routine drug treatment plus Yiqi Wenyang Huoxue Fang created by Professor Yandexin. In control group, 30 patients underwent routine treatment. The levels of left ventricular ejection fraction (LVEF), B-natriuretic peptide (BNP), Forced expiratory volume in one second (FEVn 1)/Forced expiratory volume (FVC) and quality of life score of the two groups were compared.n Results:After treatment, the BNP in the treatment group was lower than that in the control group [(218.50 ± 25.64) ng/L vs. (211.60 ± 29.51) ng/L], the LVEF in the treatment group was higher than that in the control group [(58.83 ± 3.16)% vs. (52.80 ± 4.23)%], FEVn 1/FVC and quality of life score were higher than those in the control group [(89.13 ± 3.44) scores vs. (76.90 ± 3.79) scores, (79.27 ± 5.71) scores vs. (70.30 ± 5.49) scores], and there were significant differences (n P<0.05). There were no significant changes in kidney function, coagulation function and electrocardiogram in treatemnt group before and after treatment.n Conclusions:Treatment of chronic cor pulmonale with traditional Chinese medicine Yiqi Wenyang Huoxue on the basis of conventional western medicine can significantly improve the clinical curative effect of the disease, reduce the burden on the heart and improve the quality of life.
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