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目的 探讨糖尿病患者的高脂血症与血浆内皮素(ET)关系。方法 以放射免疫法测定尿白蛋白排泄量正常的 2型糖尿病患者 10 7例、原发性高脂血症患者 6 9例和健康对照组 2 6例的血浆ET ;按血清甘油三脂 (TG)、胆固醇(TC)水平将糖尿病患者分组。结果 糖尿病合并高甘油三脂血症组、高胆固醇血症组较血脂正常的糖尿病组和原发性高脂血症组血浆ET高 (P <0 0 5 ) ,糖尿病组较健康对照组的血浆ET高 (P <0 0 1) ,相关分析显示血清TC与血浆ET呈正相关 (r =0 45 2 )。结论 糖尿病合并的血脂升高可提高血浆内皮素水平 ,引起或加重血管病变
Objective To investigate the relationship between hyperlipidemia and plasma endothelin (ET) in diabetic patients. Methods Radioimmunoassay was used to measure plasma ET in 107 patients with type 2 diabetes mellitus with normal urinary albumin excretion, 69 patients with primary hyperlipidemia and 26 healthy controls. Serum triglyceride (TG) ), Cholesterol (TC) levels of diabetic patients. Results Compared with those in the hyperglycemia group and the hypercholesterolemia group, the plasma endothelin (ET) was significantly higher in the hypercholesterolemia group than in the hyperlipidemic diabetic group and the primary hyperlipidemia group (P <0.05) ET (P <0.01). Correlation analysis showed that there was a positive correlation between serum TC and plasma ET (r = 0 452). Conclusions Elevated blood lipids in diabetic patients can increase plasma endothelin level and cause or aggravate vascular lesions