:目的　观察甲钴胺对老年糖尿病周围神经病变的疗效。方法　选择老年糖尿病周围神经病变患者 6 9例 ,随机分为 2组。治疗组 36例以甲钴胺治疗 ,0 .5mg每日 1次肌注 ,共 4周后改为 0 .5mg每日 3次口服 ,服 4周 ;对照组 33例 ,以维生素B12 0 .5mg每日 1次肌注 ,共 4周后改为维生素B62 0mg每日 3次口服 ,服 4周。观察治疗前后临床症状及神经传导速度的变化。结果　治疗组感觉减退、自发性肢体疼痛、麻木改善率分别为 5 0 %、70 %和 5 6 % ,明显高于对照组的 2 0 %、2 5 %和 33% ;神经传导速度减慢有一定程度改善 ;未见明显副作用。结论甲钴胺对老年人的糖尿病周围神经病变有一定疗效 Objective To observe the effect of mecobalamin on senile diabetic peripheral neuropathy. Methods Sixty-nine elderly patients with diabetic peripheral neuropathy were selected and randomly divided into two groups. Treatment group, 36 cases of mecobalamin treatment, 0.5mg daily intramuscular injection, a total of 4 weeks later changed to 0 .5mg orally 3 times a day for 4 weeks; the control group of 33 patients with vitamin B12 0 .5mg Once a day intramuscular injection, a total of 4 weeks later changed to vitamin B62 0mg orally 3 times a day for 4 weeks. Changes of clinical symptoms and nerve conduction velocity before and after treatment were observed. Results In the treatment group, the sensory loss, spontaneous limb pain and numbness improvement rates were 50%, 70% and 56%, respectively, which were significantly higher than those in the control group (20%, 25% and 33% To a certain degree of improvement; no obvious side effects. Conclusion Mecobalamin has some effect on diabetic peripheral neuropathy in the elderly